UNSOED has collaborative activities to improve the implementation of the Tri Dharma of Higher Education, Education, Research and Community Service. This cooperation is official in the form of a document (MoU). In a period of 3 (three) years since 2017, UNSOED has had collaborations that continue to increase in number and quality with various government agencies, private companies, and the public. Until 2019, 94 documents have been signed.

Of many domestic collaborations that have been carried out, UNSOED has collaborated with leading partners including the Director General of Financial Balance, the Ministry of Finance, the Ministry of Home Affairs, the Secretariat General of the MPR RI, Bank Indonesia (BI), Director General of Public Health, Ministry of Health RI, Ministry of Communication and Informatics, Institut Teknologi Bandung (ITB), Eijkman Institute for Mocular Biology (State Ministry of Research and Technology), Universitas Terbuka (UT) Jakarta, National Archives of the Republic of Indonesia (ANRI), PT. Great Giant Pineapple, PT. Perkebunan Nusantara IX, PT. Charoen Pokphand, Agency for Meteorology, Climatology and Geophysics (BMKG) and Public Broadcasting Institute Radio Republic of Indonesia (LPP RRI). Meanwhile, cooperation with foreign countries has been carried out with Germany, Japan, Thailand, China, Malaysia, Vietnam, South Korea, Qatar, Taiwan, India, Czech, South Africa, Hungary, Slovenia, and Austria. This overseas cooperation is carried out in order to create a world-recognized university in accordance with the UNSOED 2034 vision.